The World Health Organization identifies tuberculosis (TB), caused by Mycobacterium
tuberculosis, as a leading infectious killer. Although conventional treatments for TB exist …

Phenotypic screening of an in-house library of small molecule purine derivatives against
Mycobacterium tuberculosis (Mtb) led to the identification of 2-morpholino-7-(naphthalen-2 …

The complex immunopathology of Mycobacterium tuberculosis (Mtb) is one of the main
challenges in developing a novel vaccine against this pathogen, particularly regarding …

Apart from the SARS-CoV-2 virus, tuberculosis remains the leading cause of death from a
single infectious agent according to the World Health Organization. As part of our long-term …

Pharmacologically active salicylanilides (2-hydroxy-N-phenylbenzamides) have been a
promising area of interest in medicinal chemistry-related research for quite some time. This …

In the preclinical phase of drug development, it is necessary to determine how the active
compound can pass through the biological barriers surrounding the target tissue. In vitro …

A resistência antimicrobiana representa um dos maiores desafios para a saúde pública
mundial, exigindo o desenvolvimento de novos agentes terapêuticos eficazes contra …

Univerzita Karlova, Farmaceutická fakulta v Hradci Králové Školicí pracoviště Katedra
organické chemie a bioorganické chemie Doktorský studijní program Bioorganická chemie …

Infekční nemoci jsou hrozbou pro veřejné zdraví na celém světě. Tuberkulóza, s více než 10
miliony obětí ročně, je jednou z největších. To je dále zdůrazněno rostoucím výskytem …

Previously we have shown the efficacy of a modified synthetic peptide (RF) derived from the
Herpes simplex virus-1 gD glycoprotein (228QRTVAVYSLRIAGFHG243)(Fig. 1)([1] in …