It is now well known that non-coding RNAs (ncRNAs), rather than protein-coding transcripts,
are the preponderant RNA transcripts. NcRNAs, particularly microRNAs (miRNAs), long non …

Enormous studies have corroborated that long non-coding RNAs (lncRNAs) extensively
participate in crucial physiological processes such as metabolism and immunity, and are …

Targeting RNAs with small molecules represents a new frontier in drug discovery and
development. The rich structural diversity of folded RNAs offers a nearly unlimited reservoir …

The application of a new generation of sequencing techniques has revealed that most of the
genome has already been transcribed. However, only a small part of the genome codes …

Abstract Phosphatidylinositol-3, 4, 5-trisphosphate (PtdIns (3, 4, 5) P3 or PIP3) mediates
signalling pathways as a second messenger in response to extracellular signals. Although …

MicroRNA (miRNA) have gained widespread attention for their role in diverse vascular
processes including angiogenesis, apoptosis, proliferation, and migration. Despite great …

The acquisition of cancer cell resistance to conventional chemotherapeutics is considered
the major driver of treatment failure and disease recurrence in most solid and hematological …

The traditional view of genome organization has been upended in the last decade with the
discovery of vast amounts of non–protein-coding transcription. After initial concerns that this …

Majority of the human genome is transcribed into RNAs with absent or limited protein-coding
potential. microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are two major families …

The recognition of RNA functions beyond canonical protein synthesis has challenged the
central dogma of molecular biology. Indeed, RNA is now known to directly regulate many …