People with multiple sclerosis (MS) are at risk for infections that can result in amplification of
baseline symptoms and possibly trigger clinical relapses. Vaccination can prevent infection …

The ocular surface is constantly exposed to environmental irritants, allergens and
pathogens, against which it can mount a prompt immune response to preserve its integrity …

The eye, an anatomical extension of the central nervous system (CNS), exhibits many
molecular and cellular parallels to the brain. Emerging research demonstrates that changes …

T cell trafficking into the lung is critical for lung immunity, but the mechanisms that mediate T
cell lung homing are not well understood. Here, we show that lung dendritic cells (DCs) …

Background The attempt to induce oral tolerance as a treatment for food allergy has been
hampered by a lack of sustained clinical protection. Immunotherapy by nonoral routes, such …

Developing efficacious vaccines against enteric diseases is a global challenge that requires
a better understanding of cellular recruitment dynamics at the mucosal surfaces. The current …

Adjuvants contribute to enhancing and shaping the vaccine immune response through
different modes of action. Here early biomarkers of adjuvanticity after primary immunization …

Despite the widespread use of Mycobacterium bovis BCG, the only licensed vaccine against
tuberculosis (TB), TB remains a global epidemic. To assess whether more direct targeting of …

Combinations of different delivery routes for priming and boosting represent vaccination
strategies that can modulate magnitude, quality, and localization of the immune response. A …

Transcriptomic profiling of the immune response induced by vaccine adjuvants is of critical
importance for the rational design of vaccination strategies. In this study, transcriptomics was …