Defining functional DNA elements in the human genome
With the completion of the human genome sequence, attention turned to identifying and
annotating its functional DNA elements. As a complement to genetic and comparative …
annotating its functional DNA elements. As a complement to genetic and comparative …
[HTML][HTML] Functional and mechanistic diversity of distal transcription enhancers
M Bulger, M Groudine - Cell, 2011 - cell.com
Biological differences among metazoans and between cell types in a given organism arise
in large part due to differences in gene expression patterns. Gene-distal enhancers are key …
in large part due to differences in gene expression patterns. Gene-distal enhancers are key …
The QTN program and the alleles that matter for evolution: all that's gold does not glitter
MV Rockman - Evolution, 2012 - academic.oup.com
The search for the alleles that matter, the quantitative trait nucleotides (QTNs) that underlie
heritable variation within populations and divergence among them, is a popular pursuit. But …
heritable variation within populations and divergence among them, is a popular pursuit. But …
ChIP-seq accurately predicts tissue-specific activity of enhancers
A major yet unresolved quest in decoding the human genome is the identification of the
regulatory sequences that control the spatial and temporal expression of genes. Distant …
regulatory sequences that control the spatial and temporal expression of genes. Distant …
Genomic views of distant-acting enhancers
In contrast to protein-coding sequences, the significance of variation in non-coding DNA in
human disease has been minimally explored. A great number of recent genome-wide …
human disease has been minimally explored. A great number of recent genome-wide …
Evolution of the mammalian transcription factor binding repertoire via transposable elements
Identification of lineage-specific innovations in genomic control elements is critical for
understanding transcriptional regulatory networks and phenotypic heterogeneity. We …
understanding transcriptional regulatory networks and phenotypic heterogeneity. We …
Enhancer interaction networks as a means for singular olfactory receptor expression
The transcriptional activation of one out of∼ 2800 olfactory receptor (OR) alleles is a poorly
understood process. Here, we identify a plethora of putative OR enhancers and study their in …
understood process. Here, we identify a plethora of putative OR enhancers and study their in …
Evolution of transcription factor binding in metazoans—mechanisms and functional implications
Differences in transcription factor binding can contribute to organismal evolution by altering
downstream gene expression programmes. Genome-wide studies in Drosophila …
downstream gene expression programmes. Genome-wide studies in Drosophila …
Discriminative prediction of mammalian enhancers from DNA sequence
Accurately predicting regulatory sequences and enhancers in entire genomes is an
important but difficult problem, especially in large vertebrate genomes. With the advent of …
important but difficult problem, especially in large vertebrate genomes. With the advent of …
Tuning in to the signals: noncoding sequence conservation in vertebrate genomes
Aligning and comparing genomic sequences enables the identification of conserved
sequence signatures and can enrich for coding and noncoding functional regions. In …
sequence signatures and can enrich for coding and noncoding functional regions. In …