Cardiovascular diseases (CVDs) are serious public health issues and are responsible for
nearly one-third of global deaths. Mitochondrial dysfunction is accountable for the …

Arrhythmia is characterized by abnormal heartbeat rhythms and frequencies caused by
heart pacing and conduction dysfunction. Arrhythmia is the leading cause of death in …

Background The Brugada pattern manifests as a spontaneous variability of the
electrocardiographic marker, suggesting a variability of the underlying electrical substrate …

Arrhythmia is one of the commonly heart diseases with observed abnormal heart-beat
rhythm that caused by the obstacles of cardiac activity and conduction. The arrhythmic …

Brugada syndrome (BrS) is an inherited and rare cardiac arrhythmogenic disease
associated with an increased risk of ventricular fibrillation and sudden cardiac death …

Acacetin (5, 7‐dihydroxy‐4′‐methoxyflavone) is the major bioactive component of the
traditional Chinese medicine “Snow lotus”. As a natural flavonoid compound, it has been …

Among the inherited ion channelopathies associated with potentially life-threatening
ventricular arrhythmia syndromes in nominally structurally normal hearts are the J wave …

Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality,
imposing an increasing global health burden. Cardiac ion channels (voltage-gated Na V, Ca …

Primary electrical heart diseases, often considered channelopathies, are inherited genetic
abnormalities of cardiomyocyte electrical behavior carrying the risk of malignant arrhythmias …

Background: The transient outward current (Ito) that mediates early (phase 1) repolarization
is conducted by the KCND3-encoded Kv4. 3 pore-forming α-subunit. KCND3 gain-of …