Epstein-Barr virus (EBV) is usually acquired silently early in life and carried thereafter as an
asymptomatic infection of the B lymphoid system. However, many circumstances disturb the …

Lymphocytes expressing a T cell receptor (TCR) composed of Vgamma9 and Vdelta2
chains represent a minor fraction of human thymocytes. Extrathymic selection throughout …

Purpose: Cancer vaccines aim to generate and maintain antitumor immune responses. We
designed a phase I/IIa clinical trial to test a vaccine formulation composed of Montanide ISA …

Reconstitution of the T cell repertoire after allogeneic stem cell transplantation is a long and
often incomplete process. As a result, reactivation of Epstein-Barr virus (EBV) is a frequent …

Abstract Purpose of Review The genetic susceptibility and dominant protection for type 1
diabetes (T1D) associated with human leukocyte antigen (HLA) haplotypes, along with …

Older adults often show signs of impaired CD8+ T‐cell immunity, reflected by weaker
responses against new infections and vaccinations, and decreased protection against …

Pre-existing pathogen-specific memory T cell responses can contribute to multiple adverse
outcomes including autoimmunity and drug hypersensitivity. How the specificity of the T cell …

Introduction The avidity of the T-cell receptor (TCR) for antigenic peptides presented by the
MHC (pMHC) on cells is an essential parameter for efficient T cell-mediated immunity. Yet …

The functional avidity (FA) of cytotoxic CD8 T cells impacts strongly on their functional
capabilities and correlates with protection from infection and cancer. FA depends on TCR …

It is known that for achieving high affinity antibody responses, vaccines must be optimized
for antigen dose/density, and the prime/boost interval should be at least 4 weeks. Similar …