Soon after they were first described in 1990, aptamers were largely recognized as a new
class of biological ligands that can rival antibodies in various analytical, diagnostic, and …

This review is focused on the structural and physicochemical aspects of metal cation
coordination to G-Quadruplexes (GQ) and their effects on GQ stability and conformation. G …

DNA has played an early and powerful role in the development of bottom-up
nanotechnologies, not least because of DNA's precise, predictable, and controllable …

Aptamers are single-stranded DNA or RNA molecules capable of tightly binding to specific
targets. These functional nucleic acids are obtained by an in vitro Darwinian evolution …

Abstract Guanine-quadruplexes (G4s) are non-canonical four-stranded structures that can
be formed in guanine (G) rich nucleic acid sequences. A great number of G-rich sequences …

Nucleic acid aptamers have minimal immunogenicity, high chemical synthesis production,
low cost and high chemical stability when compared with antibodies. However, the …

Following extensive evidence for the formation of four-stranded DNA G-quadruplex
structures in vitro, DNA G-quadruplexes have been observed within human cells. Although …

Within the last decade, the application range of aptamers in biochemistry and medicine has
expanded rapidly. More than just a replacement for antibodies, these intrinsically structured …

RNA structures in the untranslated regions (UTRs) of mRNAs influence post-transcriptional
regulation of gene expression. Much of the knowledge in this area depends on canonical …

Systematic evolution of ligand by exponential enrichment (SELEX) is an efficient method
used to isolate high-affinity single stranded oligonucleotides from a large random sequence …