Endoplasmic reticulum–associated protein degradation
L Krshnan, ML van de Weijer… - Cold Spring Harbor …, 2022 - cshperspectives.cshlp.org
Misfolded, potentially toxic proteins in the lumen and membrane of the endoplasmic
reticulum (ER) are eliminated by proteasomes in the cytosol through ER-associated …
reticulum (ER) are eliminated by proteasomes in the cytosol through ER-associated …
Quality control in the endoplasmic reticulum: crosstalk between ERAD and UPR pathways
Endoplasmic reticulum (ER)-associated degradation (ERAD) and the unfolded protein
response (UPR) are two key quality-control machineries in the cell. ERAD is responsible for …
response (UPR) are two key quality-control machineries in the cell. ERAD is responsible for …
SEL1L–HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool
Stimulator of interferon genes (STING) orchestrates the production of proinflammatory
cytokines in response to cytosolic double-stranded DNA; however, the pathophysiological …
cytokines in response to cytosolic double-stranded DNA; however, the pathophysiological …
Biallelic Cys141Tyr variant of SEL1L is associated with neurodevelopmental disorders, agammaglobulinemia, and premature death
Suppressor of lin-12-like–HMG-CoA reductase degradation 1 (SEL1L-HRD1) ER-
associated degradation (ERAD) plays a critical role in many physiological processes in …
associated degradation (ERAD) plays a critical role in many physiological processes in …
Hypomorphic variants of SEL1L-HRD1 ER-associated degradation are associated with neurodevelopmental disorders
Recent studies using cell type–specific knockout mouse models have improved our
understanding of the pathophysiological relevance of suppressor of lin-12-like–HMG-CoA …
understanding of the pathophysiological relevance of suppressor of lin-12-like–HMG-CoA …
New insights into the physiological role of endoplasmic reticulum-associated degradation
Many human diseases are associated with mutations causing protein misfolding and
aggregation in the endoplasmic reticulum (ER). ER-associated degradation (ERAD) is a …
aggregation in the endoplasmic reticulum (ER). ER-associated degradation (ERAD) is a …
Endoplasmic reticulum–associated degradation regulates mitochondrial dynamics in brown adipocytes
Z Zhou, M Torres, H Sha, CJ Halbrook… - Science, 2020 - science.org
The endoplasmic reticulum (ER) engages mitochondria at specialized ER domains known
as mitochondria-associated membranes (MAMs). Here, we used three-dimensional high …
as mitochondria-associated membranes (MAMs). Here, we used three-dimensional high …
Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies
Proteolysis targeting chimeras (PROTACs) are heterobifunctional small molecules that
utilize the ubiquitin proteasome system (UPS) to degrade proteins of interest (POI) …
utilize the ubiquitin proteasome system (UPS) to degrade proteins of interest (POI) …
[HTML][HTML] Muscle-specific ER-associated degradation maintains postnatal muscle hypertrophy and systemic energy metabolism
B Abdon, Y Liang, D da Luz Scheffer, M Torres… - JCI insight, 2023 - ncbi.nlm.nih.gov
The growth of skeletal muscle relies on a delicate equilibrium between protein synthesis and
degradation; however, how proteostasis is managed in the endoplasmic reticulum (ER) is …
degradation; however, how proteostasis is managed in the endoplasmic reticulum (ER) is …
ER-associated degradation in health and disease–from substrate to organism
A Bhattacharya, L Qi - Journal of Cell Science, 2019 - journals.biologists.com
The recent literature has revolutionized our view on the vital importance of endoplasmic
reticulum (ER)-associated degradation (ERAD) in health and disease. Suppressor/enhancer …
reticulum (ER)-associated degradation (ERAD) in health and disease. Suppressor/enhancer …