The in vitro study of TNF promoter polymorphism (SNP) function was stimulated by the
numerous case–control (association) studies of the polymorphisms in relation to human …

Immunologically mediated drug reactions have been traditionally classified as unpredictable
based on the fact that they cannot be predicted strictly on the pharmacological action of the …

Individuals with rheumatoid arthritis frequently have autoantibodies to citrullinated peptides,
suggesting the involvement of the peptidylarginine deiminases citrullinating enzymes …

In 1999, Genes and Immunity published a systematic review and on-line database of
cytokine gene polymorphism in human disease, 1 and in 2001 a supplement to the review …

Rheumatoid arthritis is a common complex genetic disease, and, despite a significant
genetic element, no gene other than HLA-DRB1 has been clearly demonstrated to be …

Infliximab (anti-TNF-α monoclonal antibody) induces remission in 30–40% of Crohn's
disease patients. Treatment response is a stable trait. Two cohorts from independent …

Objective Tumor necrosis factor (TNF) is a powerful mediator of inflammation in rheumatoid
arthritis (RA). In vivo, its acute effects are limited by binding to soluble receptors (TNFR) …

A major goal of current human genome-wide studies is to identify the genetic basis of
complex disorders. However, the availability of an unbiased, reliable, cost efficient and …

OBJECTIVES Crohn's disease (CD) is a chronic inflammatory disease of the gut associated
with allelic variants of CARD15 and HLA-DRB1 genes. We investigated the prevalence and …

Introduction Interstitial Lung Disease (ILD) is frequently associated with Rheumatoid Arthritis
(RA) as one of extra-articular manifestations. Many studies for Human Leukocyte Antigen …