Advancement of a high-dose infant air-jet dry powder inhaler (DPI) with passive cyclic loading: Performance tuning for different formulations

C Howe, MAM Momin, G Aladwani, S Strickler… - International Journal of …, 2023 - Elsevier
There is a current medical need for a dry powder aerosol delivery device that can be used to
efficiently and consistently administer high dose therapeutics, such as inhaled antibiotics …

Use of computational fluid dynamics (CFD) dispersion parameters in the development of a new DPI actuated with low air volumes

W Longest, D Farkas, K Bass, M Hindle - Pharmaceutical research, 2019 - Springer
Purpose To determine the predictive power of computational fluid dynamics (CFD)-based
dispersion parameters in the development of a new inline DPI that is actuated with low …

Development of a high-dose infant air-jet dry powder inhaler (DPI) with passive cyclic loading of the formulation

C Howe, MAM Momin, G Aladwani, M Hindle… - Pharmaceutical …, 2022 - Springer
Purpose The objective of this study was to incorporate a passive cyclic loading strategy into
the infant air-jet dry powder inhaler (DPI) in a manner that provides high efficiency aerosol …

Efficient nose-to-lung aerosol delivery with an inline DPI requiring low actuation air volume

D Farkas, M Hindle, PW Longest - Pharmaceutical Research, 2018 - Springer
Purpose To demonstrate efficient aerosol delivery through an in vitro nasal model using a
dry powder inhaler (DPI) requiring low actuation air volumes (LV) applied during low-flow …

Excipient Enhanced Growth Aerosol Surfactant Replacement Therapy in an In Vivo Rat Lung Injury Model

FJ Kamga Gninzeko, MS Valentine, CK Tho… - Journal of Aerosol …, 2020 - liebertpub.com
Background: In neonatal respiratory distress syndrome, breathing support and surfactant
therapy are commonly used to enable the alveoli to expand. Surfactants are typically …

Effects of different mesh nebulizer sources on the dispersion of powder formulations produced with a new small-particle spray dryer

G Aladwani, MAM Momin, B Spence, DR Farkas… - International Journal of …, 2023 - Elsevier
The objective of this study was to explore the aerosolization performance of powders
produced with different mesh nebulizer sources in the initial design of a new small-particle …

Development and Optimization of a Low Volume Air-jet Dry Powder Inhaler (DPI) Platform for the Delivery of High Dose Aerosolized Powder to Infants

C Howe - 2022 - scholarscompass.vcu.edu
The goal of this research project was to develop an infant air-jet dry powder inhaler (DPI)
platform for high-efficiency nose-to-lung (N2L) aerosol administration to infants through …

Therapeutic Approaches for Respiratory Distress Syndrome

FJ Kamga Gninzeko - 2022 - scholarscompass.vcu.edu
Respiratory distress syndrome (RDS) is characterized by shortness of breath and low
oxygen levels. RDS affects the neonatal and adult populations. In the neonatal population …