Research over the past decade has extended the prevailing view of the mitochondrion to
include functions well beyond the generation of cellular energy. It is now recognized that …

Glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH) has long been recognized as an
important enzyme for energy metabolism and the production of ATP and pyruvate through …

Cancer cells acquire an unusual glycolytic behavior relative, to a large extent, to their
intracellular alkaline pH (pH i). This effect is part of the metabolic alterations found in most, if …

Controversy has surrounded a role for apoptosis in the loss of neurons in Parkinson's
disease (PD). Although a variety of evidence has supported an apoptotic contribution to PD …

Research over the last decade has extended the prevailing view of mitochondria to include
functions well beyond the critical bioenergetics role in supplying ATP. It is now recognized …

▪ Abstract Increasing evidence supports the notion that glyceraldehyde-3-phosphate
dehydrogenase (GAPDH) is a protein with multiple functions, including its surprising role in …

Here, we review current evidence pointing to the function of VDAC1 in cell life and death,
and highlight these functions in relation to cancer. Found at the outer mitochondrial …

Single-gene disorders with" simple" Mendelian inheritance do not always imply that there
will be an easy prediction of the phenotype from the genotype, which has been shown for a …

Background Yeasts are attractive expression platforms for many recombinant proteins, and
there is evidence for an important interrelation between the protein secretion machinery and …

Thiol proteins are important in cellular antioxidant defenses and redox signalling. It is
postulated that reactive oxidants cause selective thiol oxidation, but relative sensitivities of …