The intercalated disc (ID) is a highly specialized structure that connects cardiomyocytes via
mechanical and electrical junctions. Although described in some detail by light microscopy …

One of the factors limiting the translation of knowledge from preclinical studies to the clinic
has been the limitations of in vivo diseases models. Except in the case of highly controlled …

Background: Orai1 is a critical ion channel subunit, best recognized as a mediator of store-
operated Ca2+ entry (SOCE) in nonexcitable cells. SOCE has recently emerged as a key …

Aims Despite improvements in patient identification and management, heart failure (HF)
remains a major public health burden and an important clinical challenge. A variety of …

BACKGROUND: Heart failure causes changes in Cx43 (Connexin43) regulation that are
associated with arrhythmic heart disease. Pyk2 (proline-rich tyrosine kinase 2) is activated in …

Background Hyperglycemia-induced chronic inflammation is a crucial risk factor that causes
undesirable cardiac alternations in diabetic cardiomyopathy (DCM). Focal adhesion kinase …

Aging is a highly complex molecular process, affecting nearly all tissue systems in humans
and is the highest risk factor in developing neurodegenerative disorders such as Alzheimer's …

Identification of proteins that interact with Cx43 has been instrumental in the understanding
of gap junction (GJ) regulation. An in vitro phosphorylation screen identified that Protein …

Aims Endothelial nitric oxide (NO) synthase (eNOS) is known to play a cardioprotective
protective. However, the molecular mechanisms regulating eNOS activity during …

Cardiac structural changes associated with dilated cardiomyopathy (DCM) include
cardiomyocyte hypertrophy and myocardial fibrosis. Connective tissue growth factor (CTGF) …