Cardiovascular disease, and particularly heart failure, is still a serious health care issue for
which novel treatments and biomarkers are needed. The RNA family comprises different …

Cardiac fibrosis is one of the main characteristics of diabetic cardiomyopathy and manifests
excessive accumulation of extracellular matrix proteins in the heart. Several signaling …

Ferroptosis is an iron-dependent programmed cell death characterized by the accumulation
of reactive oxygen species (ROS). Long-term high fat diet (HFD) was found to be associated …

Rationale: Studies have demonstrated that exosomes can repair cardiac tissue post–
myocardial infarction and recapitulate the benefits of cellular therapy. Objective: We …

Diabetic Nephropathy (DN) is a chronic complication of diabetes and the primary cause of
end stage renal disease. Differential diagnosis for DN requires invasive histological …

Background Atrial fibrillation (AF) is one of the most prevalent sustained arrhythmias,
however, epidemiological data may understate its actual prevalence. Meanwhile, AF is …

Aim Chronic heart failure (CHF) can be classified as heart failure with preserved ejection
fraction (HFpEF) or with reduced ejection fraction (HFrEF). Currently, there is an unmet need …

Context Mechanisms mediating the cardiovascular and renal protection exerted by SGLT2
inhibitors are still partially unknown. We investigated whether dapagliflozin modulates …

Background: Limited knowledge exists of the extent of epigenetic alterations, such as DNA
methylation, in heart failure (HF). We conducted targeted DNA methylation sequencing to …

Noncoding RNAs (ncRNAs), which include circular RNAs (circRNAs) and microRNAs
(miRNAs), regulate the development of cardiovascular diseases (CVD). Notably, circRNAs …