Genetically identical cells exposed to the same environmental conditions can show
significant variation in molecular content and marked differences in phenotypic …

Mathematical modeling and computational analysis are essential for understanding the
dynamics of the complex gene networks that control normal development and homeostasis …

Praise for the first edition:… superb, beautifully written and organized work that takes an
engineering approach to systems biology. Alon provides nicely written appendices to …

At publication, The Control Handbook immediately became the definitive resource that
engineers working with modern control systems required. Among its many accolades, that …

Gene-gene interactions are crucial to the control of sub-cellular processes but our
understanding of their stochastic dynamics is hindered by the lack of simulation methods …

Complex networks, comprised of individual elements that interact with each other through
reaction channels, are ubiquitous across many scientific and engineering disciplines …

Background Fluorescent and luminescent gene reporters allow us to dynamically quantify
changes in molecular species concentration over time on the single cell level. The …

Autoregulatory feedback loops, where the protein expressed from a gene inhibits or
activates its own expression are common gene network motifs within cells. In these …

Due to the small number of copies of molecular species involved, such as DNA, mRNA and
regulatory proteins, gene expression is a stochastic phenomenon. In eukaryotic cells, the …

Control technology permeates every aspect of our lives. We rely on them to perform a wide
variety of tasks without giving much thought to the origins of the technology or how it became …