Secondary nucleation in amyloid formation

M Törnquist, TCT Michaels, K Sanagavarapu… - Chemical …, 2018 - pubs.rsc.org
Nucleation of new peptide and protein aggregates on the surfaces of amyloid fibrils of the
same peptide or protein has emerged in the past two decades as a major pathway for both …

Matter over mind: Liquid phase separation and neurodegeneration

S Elbaum-Garfinkle - Journal of Biological Chemistry, 2019 - ASBMB
Phase separation of biomolecules leading to the formation of assemblies with distinct
material properties has recently emerged as a new paradigm underlying subcellular …

The occurrence of hyperactivated platelets and fibrinaloid microclots in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

JM Nunes, A Kruger, A Proal, DB Kell, E Pretorius - Pharmaceuticals, 2022 - mdpi.com
We have previously demonstrated that platelet-poor plasma (PPP) obtained from patients
with Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is characterized by a …

Adsorption of azo dyes by a novel bio-nanocomposite based on whey protein nanofibrils and nano-clay: Equilibrium isotherm and kinetic modeling

SR Aqdam, DE Otzen, NM Mahmoodi… - Journal of Colloid and …, 2021 - Elsevier
Excessive discharge of synthetic azo dyes into the aquatic ecosystem is a global concern.
Here, we develop a green approach to remediate dye pollutants by fabricating an easily …

[HTML][HTML] Disruption of nuclear envelope integrity as a possible initiating event in tauopathies

M Prissette, W Fury, M Koss, C Racioppi, D Fedorova… - Cell reports, 2022 - cell.com
The microtubule-associated protein tau is an abundant component of neurons of the central
nervous system. In Alzheimer's disease and other neurodegenerative tauopathies, tau is …

In situ self‐assembled nanofibers precisely target cancer‐associated fibroblasts for improved tumor imaging

XX Zhao, LL Li, Y Zhao, HW An, Q Cai… - Angewandte …, 2019 - Wiley Online Library
Tumor complexity makes the development of highly sensitive tumor imaging probes an
arduous task. Here, we construct a peptide‐based near‐infrared probe that is responsive to …

Degradation of neurodegenerative disease-associated TDP-43 aggregates and oligomers via a proteolysis-targeting chimera

YL Tseng, PC Lu, CC Lee, RY He, YA Huang… - Journal of biomedical …, 2023 - Springer
Background Amyotrophic lateral sclerosis (ALS) associated with TAR DNA-binding protein
43 (TDP-43) aggregation has been considered as a lethal and progressive motor neuron …

Lung endothelium, tau, and amyloids in health and disease

R Balczon, MT Lin, S Voth, AR Nelson… - Physiological …, 2024 - journals.physiology.org
Lung endothelia in the arteries, capillaries, and veins are heterogeneous in structure and
function. Lung capillaries in particular represent a unique vascular niche, with a thin yet …

Hyperphosphorylated tau (p-tau) and drug discovery in the context of Alzheimer's disease and related tauopathies

KBE Moore, TJ Hung, JS Fortin - Drug discovery today, 2023 - Elsevier
Highlights•Dementia involves the chronic and progressive deterioration of cognitive
functions.•Alzheimer's disease is the most common form of dementia.•Abnormally …

Early events in amyloid-β self-assembly probed by time-resolved solid state NMR and light scattering

J Jeon, WM Yau, R Tycko - Nature Communications, 2023 - nature.com
Self-assembly of amyloid-β peptides leads to oligomers, protofibrils, and fibrils that are likely
instigators of neurodegeneration in Alzheimer's disease. We report results of time-resolved …