Methotrexate (MTX) is significantly more effective than and has a considerable advantage
over placebo in patients with severe and persistent rheumatoid arthritis (RA). The drug is …

During the past decade, major advances have been made in the accurate diagnosis of
severe cutaneous adverse reactions (SCARs) to drugs, management of their manifestations …

This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

Dermatology, edited by world authorities Jean L. Bolognia, MD, Joseph L. Jorizzo, MD, and
Julie V. Schaffer, MD, is an all-encompassing medical reference book that puts the latest …

Toxic epidermal necrolysis is a life-threatening, typically drug-induced mucocutaneous
disease. It is clinically characterized as a widespread sloughing of the skin and mucosa …

Eosinophilic esophagitis (EoE) is a chronic disease characterized clinically by symptoms of
esophageal dysfunction and histologically by eosinophil‐predominant inflammation. EoE is …

Stevens–Johnson syndrome has long been considered to resemble erythema multiforme
with mucosal involvement, but is now thought to form a single disease entity with toxic …

Most of the genes in the major histocompatibility complex (MHC) region express high
polymorphism that is fundamental for their function. The most important function of human …

Abstract HLA-A* 31: 01 was reported to be associated with carbamazepine (CBZ)-induced
severe cutaneous adverse reactions (SCAR), including drug reaction with eosinophilia and …

Purpose: Immunotherapy has experienced impressive progress in cancer treatment.
Antibodies against PD-1 improved survival in different types of cancer including melanoma …