Planar cell polarity (PCP) is an essential feature of animal tissues, whereby distinct polarity
is established within the plane of a cell sheet. Tissue-wide establishment of PCP is driven by …

Neural tube defects are severe congenital malformations affecting around one in every 1000
pregnancies. An innovation in clinical management has come from the finding that closure of …

Planar cell polarity (PCP), the orientation and alignment of cells within a sheet, is a
ubiquitous cellular property that is commonly governed by the conserved set of proteins …

Animal development requires a carefully orchestrated cascade of cell fate specification
events and cellular movements. A surprisingly small number of choreographed cellular …

Abstract Background Autism spectrum disorders (ASDs) comprise a range of
neurodevelopmental conditions of varying severity, characterized by marked qualitative …

Gastrulation and neurulation are successive morphogenetic processes that play key roles in
shaping the basic embryonic body plan. Importantly, they operate through common cellular …

Neural tube defects (NTDs), including spina bifida and anencephaly, represent the most
severe and common malformations of the central nervous system affecting 0.7–3 per 1000 …

A variety of human birth defects originate in failure of closure of the embryonic neural tube.
The genetic cause of the most common nonsyndromic defects, spina bifida (SB) or …

Planar cell polarity (PCP) is complementary to the intrinsic polarization of single cells and
refers to the global coordination of cell behaviour in the plane of a tissue and, by extension …

The ability of the immune system to protect the body from attack by foreign antigens is
essential for human survival. The immune system can, however, start to attack the body's …