GH plays a pivotal role in regulating body growth and development, which is modulated by
sex steroids. A close interplay between estrogen and GH leads to attainment of …

The fast technological development, particularly single nucleotide polymorphism array, array-
comparative genomic hybridization, and whole exome sequencing, has led to the discovery …

Clinical and laboratory investigations starting in 1958 of a group of dwarfed children
resembling isolated GH deficiency but who had very high serum levels of GH led to the …

GH insensitivity (GHI) presents in childhood as growth failure and in its severe form is
associated with dysmorphic and metabolic abnormalities. GHI may be caused by genetic …

Growth hormone (GH) insensitivity syndrome (GHIS) is a rare clinical condition in which
production of insulin-like growth factor 1 is blunted and, consequently, postnatal growth …

Abstract Laron Syndrome (LS)[OMIm# 262500], or primary GH insensitivity, was first
described in 1966 in consanguineous Jewish families from Yemen. LS is characterized by a …

Since human pituitary growth hormone (GH) became available for treatment in 1960,
followed in 1985 by recombinant human GH (rhGH), the diagnosis of GH deficiency (GHD) …

The present state of knowledge about growth hormone binding proteins (GHBP) is reviewed,
with particular emphasis on the high affinity GHBP, which represents the circulating …

The application of the powerful tool molecular biology has made it possible to ask questions
not only about hormone production and action but also to characterize many of the receptor …

IGF-I generation tests were developed over 20 yr ago and are currently used in
differentiating GH insensitivity (GHI) from other disorders characterized by low serum IGF-I …