Polygenic Risk Scores Driving Clinical Change in Glaucoma

A Kolovos, MM Hassall, OM Siggs… - Annual Review of …, 2024 - annualreviews.org
Glaucoma is a clinically heterogeneous disease and the world's leading cause of
irreversible blindness. Therapeutic intervention can prevent blindness but relies on early …

[HTML][HTML] Targeted Screening for Cancer: Learnings and Applicability to Melanoma: A Scoping Review

L Zheng, AK Smit, AE Cust, M Janda - Journal of Personalized Medicine, 2024 - mdpi.com
This scoping review aims to systematically gather evidence from personalized cancer-
screening studies across various cancers, summarize key components and outcomes, and …

The potential impact of dietary choices on melanoma risk: an anti-inflammatory diet

C Fortes, S Mastroeni, L Levati, M Alotto, F Ricci… - Genes & Nutrition, 2024 - Springer
The role of inflammation in the aetiology of cancer is recognized. However, no study yet
examined the association between an anti-inflammatory diet and cutaneous melanoma and …

[HTML][HTML] Polygenic Risk Score Improves Melanoma Risk Assessment in a Patient Cohort from the Veneto Region of Italy

S Pellegrini, TP Potjer, P Del Bianco, A Vecchiato… - Biology, 2024 - mdpi.com
Recent genome-wide association studies (GWASs) have identified many single nucleotide
polymorphisms (SNPs) that alone weakly affect melanoma risk, but their combined effect on …

Polygenic risk scores: A conceptual overview to add PRS to your clinical toolbox

E Spaeth - Implementation of Personalized Precision Medicine, 2025 - Elsevier
Polygenic risk scores (PRS) are a newer tool available in the clinical landscape that can
assign a level of risk to your patient in a disease, or phenotype-specific manner. Polygenic …