Models of cardiac tissue electrophysiology: progress, challenges and open questions
RH Clayton, O Bernus, EM Cherry, H Dierckx… - Progress in biophysics …, 2011 - Elsevier
Models of cardiac tissue electrophysiology are an important component of the Cardiac
Physiome Project, which is an international effort to build biophysically based multi-scale …
Physiome Project, which is an international effort to build biophysically based multi-scale …
[HTML][HTML] Electromechanical model of excitable tissue to study reentrant cardiac arrhythmias
MP Nash, AV Panfilov - Progress in biophysics and molecular biology, 2004 - Elsevier
We introduce the concept of a contracting excitable medium that is capable of conducting
non-linear waves of excitation that in turn initiate contraction. Furthermore, these kinematic …
non-linear waves of excitation that in turn initiate contraction. Furthermore, these kinematic …
A model for human ventricular tissue
KHWJ Ten Tusscher, D Noble… - American Journal of …, 2004 - journals.physiology.org
The experimental and clinical possibilities for studying cardiac arrhythmias in human
ventricular myocardium are very limited. Therefore, the use of alternative methods such as …
ventricular myocardium are very limited. Therefore, the use of alternative methods such as …
A novel computational model of the human ventricular action potential and Ca transient
RESULTS. In 100 such simulated experiments we found a RMSD of 4.1451. 15 mV
(mean5SD) between estimate V (t) and data, corresponding to a very close resemblance …
(mean5SD) between estimate V (t) and data, corresponding to a very close resemblance …
A comparison of monodomain and bidomain reaction-diffusion models for action potential propagation in the human heart
A bidomain reaction-diffusion model of the human heart was developed, and potentials
resulting from normal depolarization and repolarization were compared with results from a …
resulting from normal depolarization and repolarization were compared with results from a …
A Novel Form of Short QT Syndrome (SQT3) Is Caused by a Mutation in the KCNJ2 Gene
Short QT syndrome (SQTS) leads to an abbreviated QTc interval and predisposes patients to
life-threatening arrhythmias. To date, two forms of the disease have been identified: SQT1 …
life-threatening arrhythmias. To date, two forms of the disease have been identified: SQT1 …
Minimal model for human ventricular action potentials in tissue
Modeling the dynamics of wave propagation in human ventricular tissue and studying wave
stability require models that reproduce realistic characteristics in tissue. We present a …
stability require models that reproduce realistic characteristics in tissue. We present a …
[HTML][HTML] Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation
The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …
components across multiple spatial (from ion channel to organ) and temporal (from …
A computational model of the human left-ventricular epicardial myocyte
V Iyer, R Mazhari, RL Winslow - Biophysical journal, 2004 - cell.com
A computational model of the human left-ventricular epicardial myocyte is presented. Models
of each of the major ionic currents present in these cells are formulated and validated using …
of each of the major ionic currents present in these cells are formulated and validated using …
Parameter sensitivity analysis in electrophysiological models using multivariable regression
EA Sobie - Biophysical journal, 2009 - cell.com
Computational models of electrical activity and calcium signaling in cardiac myocytes are
important tools for understanding physiology. The sensitivity of these models to changes in …
important tools for understanding physiology. The sensitivity of these models to changes in …