The immune system is highly time-of-day dependent. Pioneering studies in the 1960s were
the first to identify immune responses to be under a circadian control. Only in the last …

The adaptive arm of the immune system facilitates recognition of specific foreign pathogens
and, via the action of T and B lymphocytes, induces a fine-tuned response to target the …

Circadian biology modulates almost all aspects of mammalian physiology, disease, and
response to therapies. Emerging data suggest that circadian biology may significantly affect …

Mitochondria are dynamic organelles whose architecture changes depending on the cell's
energy requirements and other signalling events. These structural changes are collectively …

Circadian rhythms control almost all aspects of physiology and behavior, allowing temporal
synchrony of these processes between each other, as well as with the external environment …

The circadian clock regulates numerous key physiological processes and maintains cellular,
tissue, and systemic homeostasis. Disruption of circadian clock machinery influences key …

The transcription factor BMAL1 is a clock protein that generates daily or circadian rhythms in
physiological functions including the inflammatory response of macrophages. Intracellular …

Circadian clocks control the internal sleep-wake rhythmicity of 24 h which is synchronized by
the solar cycle. Circadian regulation of metabolism evolved about 2.5 billion years ago, ie …

Rheumatoid arthritis (RA) represents one of the best examples of circadian fluctuations in
disease severity. Patients with RA experience stiffness, pain, and swelling in afflicted joints …

Background Single-cell transcriptomic studies have greatly improved organ-specific insights
into macrophage polarization states are essential for the initiation and resolution of …