Transporter-guided delivery of nanoparticles to improve drug permeation across cellular barriers and drug exposure to selective cell types
Targeted nano-drug delivery systems conjugated with specific ligands to target selective cell-
surface receptors or transporters could enhance the efficacy of drug delivery and therapy …
surface receptors or transporters could enhance the efficacy of drug delivery and therapy …
Evolving drug delivery strategies to overcome the blood brain barrier
DS Hersh, AS Wadajkar, NB Roberts… - Current …, 2016 - ingentaconnect.com
The blood-brain barrier (BBB) poses a unique challenge for drug delivery to the central
nervous system (CNS). The BBB consists of a continuous layer of specialized endothelial …
nervous system (CNS). The BBB consists of a continuous layer of specialized endothelial …
Spherical nucleic acid nanoparticle conjugates as an RNAi-based therapy for glioblastoma
Glioblastoma multiforme (GBM) is a neurologically debilitating disease that culminates in
death 14 to 16 months after diagnosis. An incomplete understanding of how cataloged …
death 14 to 16 months after diagnosis. An incomplete understanding of how cataloged …
[HTML][HTML] Injectable thermoresponsive hydrogels as drug delivery system for the treatment of central nervous system disorders: A review
The central nervous system (CNS), consisting of the brain, spinal cord, and retina,
superintends to the acquisition, integration and processing of peripheral information to …
superintends to the acquisition, integration and processing of peripheral information to …
Overcoming the blood–brain tumor barrier for effective glioblastoma treatment
O Van Tellingen, B Yetkin-Arik, MC De Gooijer… - Drug Resistance …, 2015 - Elsevier
Gliomas are the most common primary brain tumors. Particularly in adult patients, the vast
majority of gliomas belongs to the heterogeneous group of diffuse gliomas, ie. glial tumors …
majority of gliomas belongs to the heterogeneous group of diffuse gliomas, ie. glial tumors …
Ultrasound-mediated delivery of paclitaxel for glioma: a comparative study of distribution, toxicity, and efficacy of albumin-bound versus cremophor formulations
Purpose: Paclitaxel shows little benefit in the treatment of glioma due to poor penetration
across the blood–brain barrier (BBB). Low-intensity pulsed ultrasound (LIPU) with …
across the blood–brain barrier (BBB). Low-intensity pulsed ultrasound (LIPU) with …
Drug delivery challenges and future of chemotherapeutic nanomedicine for glioblastoma treatment
Glioblastoma (GBM) is one of the most aggressive and deadliest central nervous system
tumors, and the current standard treatment is surgery followed by radiotherapy with …
tumors, and the current standard treatment is surgery followed by radiotherapy with …
miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma
Glioblastoma multiforme (GBM) is a lethal, therapy-resistant brain cancer consisting of
numerous tumor cell subpopulations, including stem-like glioma-initiating cells (GICs), which …
numerous tumor cell subpopulations, including stem-like glioma-initiating cells (GICs), which …
Interleukins in glioblastoma pathophysiology: implications for therapy
YT Yeung, KL McDonald, T Grewal… - British journal of …, 2013 - Wiley Online Library
Despite considerable amount of research, the poor prognosis of patients diagnosed with
glioblastoma multiforme (GBM) critically needs new drug development to improve clinical …
glioblastoma multiforme (GBM) critically needs new drug development to improve clinical …
Focused ultrasound and microbubbles-mediated drug delivery to brain tumor
The presence of blood–brain barrier (BBB) and/or blood–brain–tumor barriers (BBTB) is one
of the main obstacles to effectively deliver therapeutics to our central nervous system (CNS); …
of the main obstacles to effectively deliver therapeutics to our central nervous system (CNS); …