Helicobacter pylori: gastric cancer and beyond

DB Polk, RM Peek Jr - Nature reviews cancer, 2010 - nature.com
Helicobacter pylori is the dominant species of the human gastric microbiome, and
colonization causes a persistent inflammatory response. H. pylori-induced gastritis is the …

Mechanisms of disease: Helicobacter pylori virulence factors

Y Yamaoka - Nature reviews Gastroenterology & hepatology, 2010 - nature.com
Helicobacter pylori plays an essential role in the development of various gastroduodenal
diseases; however, only a small proportion of people infected with H. pylori develop these …

Virulence Factors of Helicobacter pylori: A Review

BM Roesler, EMA Rabelo-Gonçalves… - Clinical Medicine …, 2014 - journals.sagepub.com
Helicobacter pylori is a spiral-shaped Gram-negative bacterium that colonizes the human
stomach and can establish a long-term infection of the gastric mucosa, a condition that …

[HTML][HTML] Exploring alternative treatments for Helicobacter pylori infection

G Ayala, WI Escobedo-Hinojosa… - World journal of …, 2014 - ncbi.nlm.nih.gov
Helicobacter pylori (H. pylori) is a successful pathogen that can persist in the stomach of an
infected person for their entire life. It provokes chronic gastric inflammation that leads to the …

Infiltration to infection: key virulence players of Helicobacter pylori pathogenicity

A Bhattacharjee, OS Sahoo, A Sarkar, S Bhattacharya… - Infection, 2024 - Springer
Purpose This study aims to comprehensively review the multifaceted factors underlying the
successful colonization and infection process of Helicobacter pylori (H. pylori), a prominent …

Helicobacter pylori Infection, Virulence Genes' Distribution and Accompanying Clinical Outcomes: The West Africa Situation

EG Ofori, CA Adinortey, AS Bockarie… - BioMed research …, 2019 - Wiley Online Library
Data on Helicobacter pylori (H. pylori) infection and virulence factors in countries across
West Africa are scattered. This systematic review seeks to present an update on the status of …

Roles of the plasticity regions of Helicobacter pylori in gastroduodenal pathogenesis

Y Yamaoka - Journal of medical microbiology, 2008 - microbiologyresearch.org
Putative virulence genes of Helicobacter pylori are generally classified into three categories:
strain-specific genes, phase-variable genes and genes with variable structures/genotypes …

The Intact dupA Cluster Is a More Reliable Helicobacter pylori Virulence Marker than dupA Alone

SW Jung, M Sugimoto, S Shiota, DY Graham… - Infection and …, 2012 - Am Soc Microbiol
The duodenal ulcer promoting (dupA) gene, located in the plasticity region of Helicobacter
pylori, is associated with duodenal ulcer development. dupA was predicted to form a type IV …

Systematic review and meta-analysis: the relationship between the Helicobacter pylori dupA gene and clinical outcomes

S Shiota, O Matsunari, M Watada, K Hanada… - Gut pathogens, 2010 - Springer
Background In 2005, the first disease-specific Helicobacter pylori virulence factor that
induced duodenal ulcer and had a suppressive action on gastric cancer has been identified …

Analysis of Clinical Isolates of Helicobacter pylori in Pakistan Reveals High Degrees of Pathogenicity and High Frequencies of Antibiotic Resistance

F Rasheed, BJ Campbell, H Alfizah, A Varro… - …, 2014 - Wiley Online Library
Abstract Background Antibiotic resistance in Helicobacter pylori contributes to failure in
eradicating the infection and is most often due to point and missense mutations in a few key …