Engineered tissue for cardiac regeneration: current status and future perspectives

J Li, L Liu, J Zhang, X Qu, T Kawamura, S Miyagawa… - Bioengineering, 2022 - mdpi.com
Heart failure (HF) is the leading cause of death worldwide. The most effective HF treatment
is heart transplantation, the use of which is restricted by the limited supply of donor hearts …

Robotic search for optimal cell culture in regenerative medicine

GN Kanda, T Tsuzuki, M Terada, N Sakai, N Motozawa… - Elife, 2022 - elifesciences.org
Induced differentiation is one of the most experience-and skill-dependent experimental
processes in regenerative medicine, and establishing optimal conditions often takes years …

The role of process systems engineering in applying quality by design (QbD) in mesenchymal stem cell production

IA Udugama, S Badr, K Hirono, BX Scholz… - Computers & Chemical …, 2023 - Elsevier
This manuscript discusses the role of process systems engineering (PSE) in ensuring quality
manufacturing of Mesenchymal Stem Cells (MSCs) through seeding, cultivation, and …

LLMs can generate robotic scripts from goal-oriented instructions in biological laboratory automation

T Inagaki, A Kato, K Takahashi, H Ozaki… - arXiv preprint arXiv …, 2023 - arxiv.org
The use of laboratory automation by all researchers may substantially accelerate scientific
activities by humans, including those in the life sciences. However, computer programs to …

[HTML][HTML] Automated phenol-chloroform extraction of high molecular weight genomic DNA for use in long-read single-molecule sequencing

AW Liu, A Villar-Briones, NM Luscombe… - F1000Research, 2022 - ncbi.nlm.nih.gov
Background: Automation has increasingly become more commonplace in the research
laboratory workspace. The introduction of articulated robotic arms allows the researcher …

An architecture for collaboration in systems biology at the age of the Metaverse

E Jacopin, Y Sakamoto, K Nishida, K Kaizu… - NPJ Systems Biology …, 2024 - nature.com
As the current state of the Metaverse is largely driven by corporate interests, which may not
align with scientific goals and values, academia should play a more active role in its …

Optimal scheduling for laboratory automation of life science experiments with time constraints

TD Itoh, T Horinouchi, H Uchida… - SLAS …, 2021 - journals.sagepub.com
In automated laboratories consisting of multiple different types of instruments, scheduling
algorithms are useful for determining the optimal allocations of instruments to minimize the …

ReBiA—Robotic Enabled Biological Automation: 3D Epithelial Tissue Production

L Königer, C Malkmus, D Mahdy, T Däullary… - Advanced …, 2024 - Wiley Online Library
Abstract The Food and Drug Administration's recent decision to eliminate mandatory animal
testing for drug approval marks a significant shift to alternative methods. Similarly, the …

Culturing cells for life: innovative approaches in macroscopic and microfluidic cultures, with an emphasis on stem cells

S Badilescu, SS Parimalam… - Frontiers in …, 2023 - frontiersin.org
In 2006, Whitesides, writing about microfluidics, said that microfluidics is in early
adolescence and it is not yet clear how it will develop. Today, almost 20 years later …

Automating Care by Self-maintainability for Full Laboratory Automation

K Ochiai, Y Tahara-Arai, A Kato, K Kaizu… - arXiv preprint arXiv …, 2025 - arxiv.org
The automation of experiments in life sciences and chemistry has significantly advanced
with the development of various instruments and AI technologies. However, achieving full …