Platinum-based anticancer drugs, including cisplatin, carboplatin, oxaliplatin, nedaplatin,
and lobaplatin, are heavily applied in chemotherapy regimens. However, the intrinsic or …

Glioblastoma multiforme (GBM) is the most common and lethal cancer of the adult brain,
remaining incurable with a median survival time of only 15 months. In an effort to identify …

Platinum-based drugs have maintained their preeminent position in cancer treatment
regimens even four decades after the approval of cisplatin. Although these agents have …

Glioblastoma is the most aggressive brain tumor and, even with the current multimodal
therapy, is an invariably lethal cancer with a life expectancy that depends on the tumor …

Non-coding RNAs (ncRNAs) have been implicated in most cellular functions. The disruption
of their function through somatic mutations, genomic imprinting, transcriptional and post …

Innate and acquired chemoresistance exhibited by most tumours exposed to conventional
chemotherapeutic agents account for the majority of relapse cases in cancer patients. Such …

Glioma, as one of the most severe human malignancies, is defined as the Central Nervous
System's (CNS) tumors. Glioblastoma (GBM) in this regard, is the most malignant type of …

The mammalian brain is made up of billions of neurons and supporting cells (glial cells),
intricately connected. Molecular perturbations often lead to neurodegeneration by …

Glioma is characterized by a high recurrence rate, short survival times, high rates of mortality
and treatment difficulties. Surgery, chemotherapy and radiation (RT) are the standard …

Cisplatin is an extensively used chemotherapeutic substance for various types of human
malignancies including sarcomas, carcinomas and lymphomas. Yet, the vast application of …