Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

▪ Abstract A vast number of proteins are involved in synaptic function. Many have been
cloned and their functional role defined with varying degrees of success, but their number …

Glutamate receptor ion channels mediate excitatory responses at the majority of CNS
synapses. They are the only ligand-gated ion channels for which multiple high-resolution …

We have used site-directed mutagenesis of amino acids located within the S1 and S2 ligand
binding domains of the NR2A N-methyl-d-aspartate (NMDA) receptor subunit to explore the …

The NMDA receptor plays a critical role in the development of the central nervous system
and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this …

We report the crystal structure of the glycosylated ligand-binding (S1S2) domain of the
kainate receptor subunit GluR6, in complex with the agonist domoate. The structure shows …

Ionotropic glutamate receptors mediate the vast majority of fast excitatory synaptic
transmission in the CNS. Elucidating the structure of these proteins is central to …

Ionotropic glutamate receptors (iGluRs) constitute a family of ligand-gated ion channels that
are essential for mediating fast synaptic transmission in the central nervous system. These …

Glutamic acid (Glu) is the major excitatory neurotransmitter in the mammalian central
nervous system (CNS) where it is involved in the physiological regulation of different …