The heat shock proteins (HSPs) are ubiquitous and conserved protein families in both
prokaryotic and eukaryotic organisms, and they maintain cellular proteostasis and protect …

Cell cycle progression is a tightly regulated process by which DNA replicates and cell
reproduces. The major driving force underlying cell cycle progression is the sequential …

Ubiquitin signaling is a conserved, widespread, and dynamic process in which protein
substrates are rapidly modified by ubiquitin to impact protein activity, localization, or stability …

Since the first identification of hypoxic cells in sections of carcinomas in the 1950s, hypoxia
has been known as a central hallmark of cancer cells and their microenvironment. Indeed …

Advanced stages of cancer are highly associated with short overall survival in patients due
to the lack of long-term treatment options following the standard form of care. New options …

Purpose: Therapies directed to specific molecular targets are still unmet for patients with
triple-negative breast cancer (TNBC). Deubiquitinases (DUB) are emerging drug targets …

The MYCN proto-oncogene is amplified in a number of advanced-stage human tumors, such
as neuroblastomas. Similar to other members of the MYC family of oncoproteins, MYCN …

Protein homeostasis deficiencies underlie various cancers and neurodegenerative
diseases. The ubiquitin-proteasome system (UPS) and autophagy are responsible for most …

Despite all the other cells that have the potential to prevent cancer development and
metastasis through tumour suppressor proteins, cancer cells can upregulate the ubiquitin …

Herpesvirus-associated ubiquitin-specific protease (HAUSP) is a USP family deubiquitinase.
HAUSP is a protein of immense biological importance as it is involved in several cellular …