Synthetic biology strategies for microbial biosynthesis of plant natural products

A Cravens, J Payne, CD Smolke - Nature communications, 2019 - nature.com
Metabolic engineers endeavor to create a bio-based manufacturing industry using microbes
to produce fuels, chemicals, and medicines. Plant natural products (PNPs) are historically …

Engineering cellular metabolism

J Nielsen, JD Keasling - Cell, 2016 - cell.com
Metabolic engineering is the science of rewiring the metabolism of cells to enhance
production of native metabolites or to endow cells with the ability to produce new products …

Engineering cofactor supply and recycling to drive phenolic acid biosynthesis in yeast

R Chen, J Gao, W Yu, X Chen, X Zhai, Y Chen… - Nature Chemical …, 2022 - nature.com
Advances in synthetic biology enable microbial hosts to synthesize valuable natural
products in an efficient, cost-competitive and safe manner. However, current engineering …

Rewiring carbon metabolism in yeast for high level production of aromatic chemicals

Q Liu, T Yu, X Li, Y Chen, K Campbell, J Nielsen… - Nature …, 2019 - nature.com
The production of bioactive plant compounds using microbial hosts is considered a safe,
cost-competitive and scalable approach to their production. However, microbial production …

Yeast systems biology: model organism and cell factory

J Nielsen - Biotechnology journal, 2019 - Wiley Online Library
For thousands of years, the yeast Saccharomyces cerevisiae (S. cerevisiae) has served as a
cell factory for the production of bread, beer, and wine. In more recent years, this yeast has …

[HTML][HTML] De novo production of resveratrol from glucose or ethanol by engineered Saccharomyces cerevisiae

M Li, KR Kildegaard, Y Chen, A Rodriguez… - Metabolic …, 2015 - Elsevier
Resveratrol is a natural antioxidant compound, used as food supplement and cosmetic
ingredient. Microbial production of resveratrol has until now been achieved by …

Engineering 4-coumaroyl-CoA derived polyketide production in Yarrowia lipolytica through a β-oxidation mediated strategy

CM Palmer, KK Miller, A Nguyen, HS Alper - Metabolic engineering, 2020 - Elsevier
Polyketides are a diverse class of molecules sought after for their valuable properties,
including as potential pharmaceuticals. Previously, we demonstrated that the oleaginous …

Engineering the oleaginous yeast Yarrowia lipolytica for high-level resveratrol production

J Sáez-Sáez, G Wang, ER Marella, S Sudarsan… - Metabolic …, 2020 - Elsevier
Resveratrol is a plant secondary metabolite with multiple health-beneficial properties.
Microbial production of resveratrol in model microorganisms requires extensive engineering …

Metabolic engineering of microorganisms for production of aromatic compounds

D Huccetogullari, ZW Luo, SY Lee - Microbial Cell Factories, 2019 - Springer
Metabolic engineering has been enabling development of high performance microbial
strains for the efficient production of natural and non-natural compounds from renewable …

Fermentation of blueberry juices using autochthonous lactic acid bacteria isolated from fruit environment: Fermentation characteristics and evolution of phenolic …

S Li, Y Tao, D Li, G Wen, J Zhou, S Manickam, Y Han… - Chemosphere, 2021 - Elsevier
In this study, 4 Lactobacillus plantarum strains and 5 Lactobacillus fermentum strains
adapting well to the unfavorable fruit system were isolated under different fruit environments …