This article reviews the involvement of the mitochondrial permeability transition pore in
necrotic and apoptotic cell death. The pore is formed from a complex of the voltage …

Mitochondria play a central role in the survival and death of neurons. The detailed
bioenergetic mechanisms by which isolated mitochondria generate ATP, sequester Ca2+ …

We report here the purification of a cytosolic protein that induces cytochrome c release from
mitochondria in response to caspase-8, the apical caspase activated by cell surface death …

We have designed short peptides composed of two functional domains, one a tumor blood
vessel'homing'motif and the other a programmed cell death-inducing sequence, and …

The apoptotic signal triggered by ligation of members of the death receptor family is
promoted by sequential activation of caspase zymogens. We show here that in a purified …

Both reactive dopamine metabolites and mitochondrial dysfunction have been implicated in
the neurodegeneration of Parkinson's disease. Dopamine metabolites, dopamine quinone …

The endoplasmic reticulum (ER) is the site of assembly of polypeptide chains destined for
secretion or routing into various subcellular compartments. It also regulates cellular …

Alterations in Ca2+ homeostasis and accumulation of unfolded proteins in the endoplasmic
reticulum (ER) lead to an ER stress response. Prolonged ER stress may lead to cell death …

Apoptosis is a type of cell death whose morphological appearance relies on the activation of
caspase-family cysteine proteases. Recently, it has become clear that inhibition of caspases …

Scientific revolution [1] implies a transformation of the world view in which a dominant
paradigm is substituted by a new one, one which furnishes an ameliorated comprehension …