Neuroendocrine neoplasms (NENs) originate from the neuroendocrine cell system, which
may either take the shape of organoid cell aggregations or be composed of dispersed cells …

Myeloid cells include various cellular subtypes that are distinguished into mononuclear and
polymorphonuclear cells, derived from either common myeloid progenitor cells (CMPs) or …

Tumor-associated inflammation and immune responses are key components in the tumor
microenvironment (TME) which regulate tumor growth, progression, and metastasis. Tumor …

Among all tumor types, skin cancers are profoundly sensitive to immunotherapy. Indeed, the
recently reported response rates for anti-PD-1 (anti-programmed-death 1) therapy for …

Immune checkpoint molecules function to inhibit and regulate immune response pathways
to prevent hyperactive immune activity from damaging healthy tissues. In cancer patients …

Patients with pediatric cancers such as neuroblastoma (NB) are often unresponsive to
checkpoint blockade immunotherapy. One major factor in pediatric tumor resistance to …

Simple Summary Pancreatic cancer is one of the most lethal types of cancer, and
immunotherapy treatment options for these patients are limited by the characteristically …

Merkel cell carcinoma (MCC) is a rare and aggressive type of skin cancer associated with a
poor prognosis. This carcinoma was named after its presumed cell of origin, the Merkel cell …

Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer that responds to PD-1/PD-
L1 immune checkpoint inhibitors. CD200 is another checkpoint modulator whose receptor is …

Around 40% of humans and Tasmanian devils (Sarcophilus harrisii) develop cancer in their
lifetime, compared to less than 10% for most species. In addition, devils are affected by two …