IMI–Report on experimental models of emmetropization and myopia

D Troilo, EL Smith, DL Nickla, R Ashby… - … & visual science, 2019 - iovs.arvojournals.org
The results of many studies in a variety of species have significantly advanced our
understanding of the role of visual experience and the mechanisms of postnatal eye growth …

Scleral structure and biomechanics

C Boote, IA Sigal, R Grytz, Y Hua, TD Nguyen… - Progress in retinal and …, 2020 - Elsevier
As the eye's main load-bearing connective tissue, the sclera is centrally important to vision.
In addition to cooperatively maintaining refractive status with the cornea, the sclera must …

Scleral hypoxia is a target for myopia control

H Wu, W Chen, F Zhao, Q Zhou… - Proceedings of the …, 2018 - National Acad Sciences
Worldwide, myopia is the leading cause of visual impairment. It results from inappropriate
extension of the ocular axis and concomitant declines in scleral strength and thickness …

Circadian rhythms, refractive development, and myopia

R Chakraborty, LA Ostrin, DL Nickla… - Ophthalmic and …, 2018 - Wiley Online Library
Purpose Despite extensive research, mechanisms regulating postnatal eye growth and
those responsible for ametropias are poorly understood. With the marked recent increases …

Candidate pathways for retina to scleral signaling in refractive eye growth

DM Brown, R Mazade, D Clarkson-Townsend… - Experimental eye …, 2022 - Elsevier
The global prevalence of myopia, or nearsightedness, has increased at an alarming rate
over the last few decades. An eye is myopic if incoming light focuses prior to reaching the …

Animal models in myopia research

F Schaeffel, M Feldkaemper - Clinical and Experimental Optometry, 2015 - Taylor & Francis
Our current understanding of the development of refractive errors, in particular myopia,
would be substantially limited had Wiesel and Raviola not discovered by accident that …

[HTML][HTML] Long-wavelength (red) light produces hyperopia in juvenile and adolescent tree shrews

TJ Gawne, AH Ward, TT Norton - Vision Research, 2017 - Elsevier
In infant tree shrews, exposure to narrow-band long-wavelength (red) light, that stimulates
long-wavelength sensitive cones almost exclusively, slows axial elongation and produces …

Decreased choroidal blood perfusion induces myopia in guinea pigs

X Zhou, S Zhang, F Yang, Y Yang… - … & Visual Science, 2021 - iovs.arvojournals.org
Purpose: The development of myopia in guinea pigs can be inhibited by attenuating scleral
hypoxia by increasing choroidal blood perfusion (ChBP). In this study, we reduced ChBP …

[HTML][HTML] Near infrared (NIR) light therapy of eye diseases: a review

Q Zhu, S Xiao, Z Hua, D Yang, M Hu… - … journal of medical …, 2021 - ncbi.nlm.nih.gov
Near infrared (NIR) light therapy, or photobiomodulation therapy (PBMT), has gained
persistent worldwide attention in recent years as a new novel scientific approach for …

The wavelength composition and temporal modulation of ambient lighting strongly affect refractive development in young tree shrews

TJ Gawne, JT Siegwart Jr, AH Ward… - Experimental eye research, 2017 - Elsevier
Shortly after birth, the eyes of most animals (including humans) are hyperopic because the
short axial length places the retina in front of the focal plane. During postnatal development …