In this brief review we discuss some aspects of the Na+ pump and its roles in mediating the
effects of ouabain and endogenous ouabain (EO): i) in regulating the cytosolic Ca 2+ …

A novel multispecific organic anion transporting polypeptide (oatp2) has been isolated from
rat brain. The cloned cDNA contains 3,640 bp. The coding region extends over 1,983 …

Objective To determine plasma levels of the endogenous bufodienolide Na+/K+ ATPase
inhibitor, marinobufagenin-like factor (MBG), in normotensive pregnancy and in …

A sodium pump inhibitor has been isolated from human plasma and extensively purified.
This material, endogenous digitalislike factor, was examined by a variety of mass …

For over three decades, renal physiology has sought a putative natriuretic hormone (third
factor) that might control the body's pool of extracellular fluid, an important determinant in …

Background—Digitalis-like sodium pump ligands (SPLs) effect natriuresis via inhibition of
renal tubular Na+, K+-ATPase but may induce vasoconstriction. The present study …

Recent evidence suggests the existence of several endogenous Na+, K+-ATPase inhibitors
in mammals. Previously, we have shown that the amphibian Na+, K+-ATPase inhibitor …

The human circulation contains four readily distinguishable biologically active inhibitors of
the sodium pump that appear to be endogenous to mammals. Of these, one has been …

Hyponatremia in acute brain disease is a common occurrence, especially after an
aneurysmal subarachnoid hemorrhage. Originally, excessive natriuresis, called cerebral salt …

The sodium pump (Na/K‐ATPase) is a plasma membrane enzyme that transports Na+ and
K+ against their physiological gradients in most eukaryotic cells. Besides pumping ions, the …