A review of transgenerational and multigenerational toxicology in the in vivo model animal Caenorhabditis elegans

Y Zhao, J Chen, R Wang, X Pu… - Journal of Applied …, 2023 - Wiley Online Library
A large number of pollutants existing in the environment can last for a long time, and their
potential toxic effects can transfer from parents to their offspring. Thus, it is necessary to …

MicroRNAs in drug addiction: Current status and future perspectives

Y Zhao, F Qin, S Han, S Li, Y Zhao, H Wang… - Pharmacology & …, 2022 - Elsevier
Drug addiction is a chronic and relapsing brain disorder characterized by compulsive drug
seeking and continued drug use despite adverse consequences. The high prevalence and …

Molecular toxicology in Caenorhabditis elegans

D Wang - Nematodes as Model Organisms, 2022 - cabidigitallibrary.org
This chapter focuses on the introduction of molecular signaling pathways involved in
regulating the toxicity of environmental toxicants or stresses in Caenorhabditis elegans …

Role of microRNAs in the pathophysiology of addiction

AM Gowen, KE Odegaard, J Hernandez… - Wiley …, 2021 - Wiley Online Library
Addiction is a chronic and relapsing brain disorder characterized by compulsive seeking
despite adverse consequences. There are both heritable and epigenetic mechanisms …

Caenorhabditis elegans as an emerging model system in environmental epigenetics

C Weinhouse, L Truong, JN Meyer… - Environmental and …, 2018 - Wiley Online Library
The roundworm Caenorhabitis elegans has been an established model organism for the
study of genetics and developmental biology, including studies of transcriptional regulation …

Nicotine Impairs Macrophage Control of Mycobacterium tuberculosis

X Bai, JA Stitzel, A Bai, CA Zambrano… - American journal of …, 2017 - atsjournals.org
Pure nicotine impairs macrophage killing of Mycobacterium tuberculosis (MTB), but it is not
known whether the nicotine component in cigarette smoke (CS) plays a role. Moreover, the …

miR-296-3p negatively regulated by nicotine stimulates cytoplasmic translocation of c-Myc via MK2 to suppress chemotherapy resistance

X Deng, Z Liu, X Liu, Q Fu, T Deng, J Lu, Y Liu, Z Liang… - Molecular Therapy, 2018 - cell.com
This study aimed to identify mechanisms by which microRNA 296-3p (miR-296-3p) functions
as a tumor suppressor to restrain nasopharyngeal carcinoma (NPC) cell growth, metastasis …

From the cover: metabolomics reveals a role of betaine in prenatal DBP exposure-induced epigenetic transgenerational failure of spermatogenesis in rats

B Yuan, W Wu, M Chen, H Gu, Q Tang… - Toxicological …, 2017 - academic.oup.com
There is increasing concern that early-life exposure to endocrine disruptors affects male
offspring reproduction. However, whether di-n-butyl phthalate (DBP), a widely used …

The impact of perinatal nicotine exposure on fetal lung development and subsequent respiratory morbidity

KM Kuniyoshi, VK Rehan - Birth defects research, 2019 - Wiley Online Library
Maternal smoking during pregnancy remains as a significant public health crisis as it did
decades ago. Although its prevalence is decreasing in high‐income countries, it has …

MicroRNA expression profiles during cotton (Gossypium hirsutum L) fiber early development

M Wang, R Sun, C Li, Q Wang, B Zhang - Scientific reports, 2017 - nature.com
The role of microRNAs (miRNAs) during cotton fiber development remains unclear. Here, a
total of 54 miRNAs belonging to 39 families were selected to characterize miRNA regulatory …