Sickle cell disease (SCD) is a common monogenetic disorder with high associated morbidity
and mortality. The pulmonary complications of SCD are of particular importance, as acute …

Acute chest syndrome (ACS) is a common complication and reason for hospital admission in
patients with sickle cell disease (SCD). It is also the most common cause of death in this …

Background: Pulmonary complications of sickle cell disease (SCD) are diverse and
encompass acute and chronic disease. The understanding of the natural history of …

Introduction Sickle cell disease, one of the world's most prevalent Mendelian disorders, is a
chronic hemolytic anemia punctuated by acute vasoocclusive events. Both hemolysis and …

In recent years, evidence has accumulated indicating that the enzyme arginase, which
converts L‐arginine into L‐ornithine and urea, plays a key role in the pathogenesis of …

Hemoglobinopathies are diseases caused by genetic mutations that result in abnormal,
dysfunctional hemoglobin molecules or lower levels of normal hemoglobin molecules. The …

The aim of this study was to assess the impact of recurrent acute chest syndrome (ACS)
episodes on the lung function of young adults with sickle cell disease (SCD). Our …

Acute chest syndrome (ACS) is a leading complication of sickle cell disease (SCD) with
significant morbidity and mortality. ACS is the most common cause of death and the second …

A physician diagnosis of asthma in children and adults with sickle cell disease (SCD) has
been associated with increased rates of pain and acute chest syndrome (ACS) episodes …

To assess the associations between a doctor diagnosis of asthma and wheezing
(independent of a diagnosis of asthma) with sickle cell disease (SCD) morbidity, we …