Chronic alcohol drinking persistently suppresses thalamostriatal excitation of cholinergic neurons to impair cognitive flexibility
Exposure to addictive substances impairs flexible decision making. Cognitive flexibility is
mediated by striatal cholinergic interneurons (CINs). However, how chronic alcohol drinking …
mediated by striatal cholinergic interneurons (CINs). However, how chronic alcohol drinking …
[HTML][HTML] Corticostriatal circuit models of cognitive impairments induced by fetal exposure to alcohol
S Bariselli, DM Lovinger - Biological psychiatry, 2021 - Elsevier
The term fetal alcohol spectrum disorder includes a group of diseases caused by fetal
alcohol exposure (FAE). Patients with fetal alcohol spectrum disorder display …
alcohol exposure (FAE). Patients with fetal alcohol spectrum disorder display …
Whole-brain mapping of direct inputs to dopamine D1 and D2 receptor-expressing medium spiny neurons in the posterior dorsomedial striatum
The posterior dorsomedial striatum (pDMS) is mainly composed of medium spiny neurons
(MSNs) expressing either dopamine D1 receptors (D1Rs) or D2Rs. Activation of these two …
(MSNs) expressing either dopamine D1 receptors (D1Rs) or D2Rs. Activation of these two …
Gestational alcohol exposure disrupts cognitive function and striatal circuits in adult offspring
VC Cuzon Carlson, CM Gremel, DM Lovinger - Nature communications, 2020 - nature.com
Fetal alcohol exposure (FAE) is the leading preventable developmental cause of cognitive
dysfunction. Even in the absence of binge drinking, alcohol consumption during pregnancy …
dysfunction. Even in the absence of binge drinking, alcohol consumption during pregnancy …
Gestational ethanol exposure impairs motor skills in female mice through dysregulated striatal dopamine and acetylcholine function
S Bariselli, Y Mateo, N Reuveni… - …, 2023 - nature.com
Fetal alcohol exposure has deleterious consequences on the motor skills of patients affected
by Fetal Alcohol Spectrum Disorder (FASD) and in pre-clinical models of gestational ethanol …
by Fetal Alcohol Spectrum Disorder (FASD) and in pre-clinical models of gestational ethanol …
Optogenetic inhibition of light‐captured alcohol‐taking striatal engrams facilitates extinction and suppresses reinstatement
Background Alcohol use disorder (AUD) is a complex condition, and it remains unclear
which specific neuronal substrates mediate alcohol‐seeking and‐taking behaviors. Engram …
which specific neuronal substrates mediate alcohol‐seeking and‐taking behaviors. Engram …
Dynamic responses of striatal cholinergic interneurons control behavioral flexibility
Striatal cholinergic interneurons (CINs) are key to regulating behavioral flexibility, involving
both extinguishing learned actions and adopting new ones. However, the mechanisms …
both extinguishing learned actions and adopting new ones. However, the mechanisms …
Optogenetic control of alcohol-seeking behavior via the dorsomedial striatal circuit
Alcohol consumption alters glutamatergic transmission in many brain regions, including the
dorsomedial striatum (DMS); this aberrant plasticity is thought to be responsible for alcohol …
dorsomedial striatum (DMS); this aberrant plasticity is thought to be responsible for alcohol …
Biomarkers of Affective Dysregulation Associated with In Utero Exposure to EtOH
N Darbinian, N Merabova, G Tatevosian, M Morrison… - Cells, 2023 - mdpi.com
Introduction: Children with fetal alcohol spectrum disorders (FASD) exhibit behavioral and
affective dysregulation, including hyperactivity and depression. The mechanisms are not …
affective dysregulation, including hyperactivity and depression. The mechanisms are not …
[HTML][HTML] Striatal μ-opioid receptor activation triggers direct-pathway GABAergic plasticity and induces negative affect
Withdrawal from chronic opioid use often causes hypodopaminergic states and negative
affect, which may drive relapse. Direct-pathway medium spiny neurons (dMSNs) in the …
affect, which may drive relapse. Direct-pathway medium spiny neurons (dMSNs) in the …