For centuries, itch was categorized as a submodality of pain. Recent research over the last
decade has led to the realization that itch is in fact a separate and distinct, albeit closely …

Although acute itch has a protective role by removing irritants to avoid further damage,
chronic itch is debilitating, significantly impacting quality of life. Over the past two decades, a …

Lichen sclerosus (LS) is an inflammatory skin disease that usually involves the anogenital
area. All patients with symptoms or signs suspicious of lichen sclerosus should be seen at …

Itch is a major indicator of psoriasis, but the underlying mechanisms behind this symptom
are largely unknown. To investigate the neuronal mechanisms of psoriatic itch, we tested …

Background and Purpose Itching is the most frequent pathology in dermatology that has
significant impacts on people's mental health and social life. Transient receptor potential …

The sensations of pain, itch, and cold often interact with each other. Pain inhibits itch,
whereas cold inhibits both pain and itch. TRPV1 and TRPA1 channels transduce pain and …

Itch is a unique sensation associated with the scratch reflex. Although the scratch reflex
plays a protective role in daily life by removing irritants, chronic itch remains a clinical …

Vulvar lichen sclerosus (VLS) is a chronic inflammatory dermatosis characterized by ivory-
white plaques or patches with glistening surface commonly affecting the vulva and anus …

Humans perceive physical information about the surrounding environment through their
senses. This physical information is registered by a collection of highly evolved and finely …

Background Allergies often present challenges in managing itch and the effects of
histamine. Cooling agents that act via transient receptor potential melastatin 8 (TRPM8) …