Fibroblast growth factor (FGF) signaling controls fundamental processes such as
proliferation, differentiation and migration throughout mammalian development. Here we …

Cells of the early mammalian embryo, including pluripotent embryonic stem (ES) cells and
primordial germ cells (PGCs), are epigenetically dynamic and heterogeneous. During early …

INTRODUCTION Early mammalian development requires the formation of embryonic and
extraembryonic tissues and a highly coordinated partnership between them. This close …

The generation of properly functioning gametes in vitro requires reconstitution of the
multistepped pathway of germ cell development. We demonstrate here the generation of …

Reconstitution of female germ cell development in vitro is a key challenge in reproductive
biology and medicine. We show here that female (XX) embryonic stem cells and induced …

Genome‐wide DNA demethylation, including the erasure of genome imprints, in primordial
germ cells (PGCs) is a critical first step to creating a totipotent epigenome in the germ line …

Developmental signals such as Wnts are often presented to cells in an oriented manner. To
examine the consequences of local Wnt signaling, we immobilized Wnt proteins on beads …

Embryonic stem cells (ESCs) are apparently homogeneous self-renewing cells, but we
observed heterogeneous expression of Stella in ESCs, which is a marker of pluripotency …

Mammalian mitochondrial DNA (mtDNA) is inherited principally down the maternal line, but
the mechanisms involved are not fully understood. Females harboring a mixture of mutant …

We previously reported that primordial germ cells (PGCs) in mice erase genome-wide DNA
methylation and histone H3 lysine9 dimethylation (H3K9me2), and instead acquire high …