Their ability to move within genomes gives transposable elements an intrinsic propensity to
affect genome evolution. Non-long terminal repeat (LTR) retrotransposons—including LINE …

Transposable elements (TEs) or “jumping genes” historically have been disparaged as a
class of “junk DNA” in mammalian genomes (1, 2). The advent of whole genome DNA …

It has been widely accepted that 5-methylcytosine is the only form of DNA methylation in
mammalian genomes. Here we identify N 6-methyladenine as another form of DNA …

The sequence of the mouse genome is a key informational tool for understanding the
contents of the human genome and a key experimental tool for biomedical research. Here …

In female mammals, most genes on one X chromosome are silenced as a result of X-
chromosome inactivation,. However, some genes escape X-inactivation and are expressed …

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Satellite repeats in heterochromatin are transcribed into noncoding RNAs that have been
linked to gene silencing and maintenance of chromosomal integrity. Using digital gene …

In somatic nuclei of female therian mammals, the two X chromosomes display very different
chromatin states: One X is typically euchromatic and transcriptionally active, and the other is …

The human X chromosome has a unique biology that was shaped by its evolution as the sex
chromosome shared by males and females. We have determined 99.3% of the euchromatic …

The completion of the human genome reference sequence ushered in a new era for the
study and discovery of human transposable elements. It now is undeniable that …