The cerebral neocortex is segregated into six horizontal layers, each containing unique
populations of molecularly and functionally distinct excitatory projection (pyramidal) neurons …

In physiological conditions, adult neurons have low intracellular Cl−[(Cl−) I] levels
underlying the γ-aminobutyric acid (GABA) ergic inhibitory drive. In contrast, neurons have …

Background CHD8 (chromodomain helicase DNA-binding protein 8), which codes for a
member of the CHD family of ATP-dependent chromatin-remodeling factors, is one of the …

We have used a translational convergent functional genomics (CFG) approach to identify
and prioritize genes involved in schizophrenia, by gene-level integration of genome-wide …

Attention deficit hyperactivity disorder (ADHD) is a common, heritable neuropsychiatric
disorder of unknown etiology. We performed a whole-genome copy number variation (CNV) …

Recent advances in our understanding of the underlying genetic architecture of psychiatric
disorders has blown away the diagnostic boundaries that are defined by currently used …

The WAVE regulatory complex (WRC) controls actin cytoskeletal dynamics throughout the
cell by stimulating the actin-nucleating activity of the Arp2/3 complex at distinct membrane …

Genome-wide expression analysis using next generation sequencing (RNA-Seq) provides
an opportunity for in-depth molecular profiling of fundamental biological processes, such as …

The construction of the brain relies on a series of well-defined genetically and experience-or
activity-dependent mechanisms which allow to adapt to the external environment. Disruption …

Neuroimaging is central to the quest for a biological foundation of psychiatric diagnosis but
so far has not yielded clinically relevant biomarkers for mental disorders. This review …