Major depressive disorder (MDD) was previously hypothesized to be a disease of
monoamine deficiency in which low levels of monoamines in the synaptic cleft were …

Objective This was a systematic review of studies that examined the impact of epidemics or
social restriction on mental and developmental health in parents and children/adolescents …

An extensive literature on childhood adversity and neurodevelopment has emerged over the
past decade. We evaluate two conceptual models of adversity and neurodevelopment—the …

Discovering the processes through which early adverse experiences affect children's
nervous-system development, health, and behavior is critically important for developing …

Emerging evidence suggests that partially distinct mechanisms may underlie the association
between different dimensions of early life adversity (ELA) and psychopathology in children …

Exposure to early life stress (ELS) causes abnormal hippocampal development and
functional deficits in rodents and humans, but no meta-analysis has been used yet to …

The dimensional model of adversity proposes that experiences of threat and deprivation
have distinct neurodevelopmental consequences. We examined these dimensions …

Smaller hippocampal volume is associated with increased risk for PTSD following trauma,
but the hippocampal functions involved remain unknown. We propose a conceptual model …

Early-life adversity (ELA), often clinically referred to as “adverse childhood experiences
(ACE),” is the exposure to stress-inducing events in childhood that can result in poor health …

Background There is considerable evidence documenting associations between early life
adversity, behavioral disengagement, and depression with blunted cardiovascular reactivity …