Prolidase (peptidase D), encoded by the PEPD gene, is a ubiquitously expressed cytosolic
metalloproteinase, the only enzyme capable of cleaving imidodipeptides containing C …

Approximately 37 million people worldwide are infected with human immunodeficiency virus
(HIV). One highly significant complication of HIV infection is the development of HIV …

Radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) often leads to
aggressive local recurrence and increased metastasis, and vascular integrity and platelets …

Prolidase (PEPD) is the only hydrolase that cleaves the dipeptides containing C-terminal
proline or hydroxyproline-the rate-limiting step in collagen biosynthesis. However, the …

Prolidase [EC 3.4. 13.9], known as PEPD, cleaves di-and tripeptides containing carboxyl-
terminal proline or hydroxyproline. For decades, prolidase has been thoroughly …

The destruction of the blood-brain barrier (BBB) contributes to a spectrum of neurological
diseases such as stroke, and the hyperpermeability of endothelial cells is one of the …

Ischemic stroke is a disease in which brain tissue is damaged by a sudden rupture or
blockage of a blood vessel in the brain that prevents blood from flowing to the brain …

Cocaine abuse has been strongly linked to blood− brain barrier (BBB) dysfunction, though
the exact mechanism by which cocaine disrupts the BBB remains unclear. In this study, we …

Background Cocaine has a variety of negative effects on the central nervous system,
including reports of decreased barrier function of brain microvascular endothelial cells …

Cocaine is a highly addictive drug, and its use is associated with adverse medical
consequences such as cerebrovascular accidents that result in debilitating neurological …