Aberrant Wnt signaling activation is frequently observed in many cancers. The mutation
acquisition of Wnt signaling leads to tumorigenesis, whereas the inhibition of Wnt signaling …

Simple Summary Wnt has diverse regulatory roles at multiple cellular levels and numerous
targeting points, and aberrant Wnt signaling has crucial roles in carcinogenesis, metastasis …

There exists a complex interaction between obesity, type 2 diabetes mellitus (T2DM) and
cancer, and an increase in the incidence of cancer is expected with the growing obesity …

Gastric cancer (GC) and colorectal cancer (CRC) are frequent and aggressive malignancies
worldwide. Despite the emergence of various therapeutic regimens, the prognosis of gastric …

Simple Summary Human primary liver cancers have a poor prognosis. At present, there are
limited treatment alternatives, and to understand the molecular aspects of liver …

Colon tumors of the mesenchymal subtype have the lowest overall survival. Snail1 is
essential for the acquisition of this phenotype, characterized by increased tumor stemness …

Importance While the incidence of early-onset metastatic colorectal cancer (mCRC) has
been increasing, studies on the age-related disparity in this group of patients are limited …

The development and progression of cancer are associated with the dysregulation of
multiple pathways involved in cell proliferation and survival, as well as dysfunction in redox …

The poor prognosis of most cases of advanced cholangiocarcinoma (CCA) constitutes a
severe problem in modern oncology, which is aggravated by the fact that the incidence of …

Inactivating mutations of the adenomatous polyposis coli (APC) gene and consequential
upregulation of the Wnt signaling pathway are critical initiators in the development of …