Iron deficiency in heart failure: mechanisms and pathophysiology

RIS Alnuwaysir, MF Hoes, DJ van Veldhuisen… - Journal of clinical …, 2021 - mdpi.com
Iron is an essential micronutrient for a myriad of physiological processes in the body beyond
erythropoiesis. Iron deficiency (ID) is a common comorbidity in patients with heart failure …

Iron overload, oxidative stress, and ferroptosis in the failing heart and liver

D Mancardi, M Mezzanotte, E Arrigo, A Barinotti… - Antioxidants, 2021 - mdpi.com
Iron accumulation is a key mediator of several cytotoxic mechanisms leading to the
impairment of redox homeostasis and cellular death. Iron overload is often associated with …

How can sodium–glucose cotransporter 2 inhibitors stimulate erythrocytosis in patients who are iron‐deficient? Implications for understanding iron homeostasis in …

M Packer - European journal of heart failure, 2022 - Wiley Online Library
Many patients with heart failure have an iron‐deficient state, which can limit erythropoiesis in
erythroid precursors and ATP production in cardiomyocytes. Yet, treatment with sodium …

Iron and the heart: A paradigm shift from systemic to cardiomyocyte abnormalities

A Paterek, U Mackiewicz… - Journal of cellular …, 2019 - Wiley Online Library
Iron is a key micronutrient for the human body and participates in biological processes, such
as oxygen transport, storage, and utilization. Iron homeostasis plays a crucial role in the …

Rationale and design of the AFFIRM‐AHF trial: a randomised, double‐blind, placebo‐controlled trial comparing the effect of intravenous ferric carboxymaltose on …

P Ponikowski, BA Kirwan, SD Anker… - European journal of …, 2019 - Wiley Online Library
Aims Iron deficiency (ID) is a common co‐morbidity in heart failure (HF), associated with
impaired functional capacity, poor quality of life and increased morbidity and mortality …

Iron deficiency in myocardial ischaemia: molecular mechanisms and therapeutic perspectives

F Corradi, G Masini, T Bucciarelli… - Cardiovascular …, 2023 - academic.oup.com
Systemic iron deficiency (SID), even in the absence of anaemia, worsens the prognosis and
increases mortality in heart failure (HF). Recent clinical–epidemiological studies, however …

[HTML][HTML] Cardiac iron metabolism during aging–Role of inflammation and proteolysis

S Walter, C Mertens, MU Muckenthaler, C Ott - Mechanisms of ageing and …, 2023 - Elsevier
Iron is the most abundant trace element in the human body. Since iron can switch between
its 2-valent and 3-valent form it is essential in various physiological processes such as …

Pre-emptive iron supplementation prevents myocardial iron deficiency and attenuates adverse remodelling after myocardial infarction

B Chung, Y Wang, M Thiel, F Rostami… - Cardiovascular …, 2023 - academic.oup.com
Aims Heart failure (HF) after myocardial infarction (MI) is a major cause of morbidity and
mortality. We sought to investigate the functional importance of cardiac iron status after MI …

Regulation of N6-methyladenosine after myocardial infarction

M Vausort, M Niedolistek, AI Lumley, M Oknińska… - Cells, 2022 - mdpi.com
Development of heart failure (HF) after myocardial infarction (MI) is responsible for
premature death. Complex cellular and molecular mechanisms are involved in this process …

Micronutrient depletion in heart failure: common, clinically relevant and treatable

N Cvetinovic, G Loncar, AM Isakovic… - International journal of …, 2019 - mdpi.com
Heart failure (HF) is a chronic condition with many imbalances, including nutritional issues.
Next to sarcopenia and cachexia which are clinically evident, micronutrient deficiency is also …