Transcriptional activation throughout the eukaryotic lineage has been tightly linked with
disruption of nucleosome organization at promoters, enhancers, silencers, insulators and …

The mixed-lineage leukemia family of histone methyltransferases (MLL1–4, or KMT2A–D)
were previously linked to cancer through the founding member, MLL1/KMT2A, which is often …

Gene regulation is a dynamic process involving changes ranging from the remodeling of
chromatin to preferential translation. To understand integrated nuclear and cytoplasmic …

Several novel recurrent mutations of histone modifying and chromatin remodeling genes
have been identified in renal cell carcinoma. These mutations cause loss of function of …

Mutations in SETD2, a histone H3 lysine trimethyltransferase, have been identified in clear
cell renal cell carcinoma (ccRCC); however it is unclear if loss of SETD2 function alters the …

KMT2 (histone-lysine N-methyltransferase subclass 2) complexes methylate lysine 4 on the
histone H3 tail at gene promoters and gene enhancers and, thus, control the process of …

Whereas VHL inactivation is a primary event in clear cell renal cell carcinoma (ccRCC), the
precise mechanism (s) of how this interacts with the secondary mutations in tumor …

Clear cell renal cell carcinoma (ccRCC) is the major subtype of kidney cancer that is
characterized by frequent inactivation of the von Hippel-Lindau (VHL) gene in 80–90% of …

Intraclonal heterogeneity of genetically modified mammalian cells has been observed as a
phenomenon that has a strong impact on overall transgene expression levels and that limits …

Kidney renal clear cell carcinoma (KIRC) is a cancer that is closely associated with
epigenetic alterations, and histone modifiers (HMs) are closely related to epigenetic …