The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …

The principal role of prolactin in mammals is the regulation of lactation. Prolactin is a
hormone that is mainly synthesized and secreted by lactotroph cells in the anterior pituitary …

Although the function of the mammalian pancreas hinges on complex interactions of distinct
cell types, gene expression profiles have primarily been described with bulk mixtures. Here …

Pancreatic islet cells are critical for maintaining normal blood glucose levels, and their
malfunction underlies diabetes development and progression. We used single-cell RNA …

To understand organ function, it is important to have an inventory of its cell types and of their
corresponding marker genes. This is a particularly challenging task for human tissues like …

Hormone-secreting cells within pancreatic islets of Langerhans play important roles in
metabolic homeostasis and disease. However, their transcriptional characterization is still …

The deleterious effect of chronic activation of the IL-1β system on type 2 diabetes and other
metabolic diseases is well documented. However, a possible physiological role for IL-1β in …

Type 1 diabetes affects millions of people globally and requires careful management to
avoid serious long-term complications, including heart and kidney disease, stroke, and loss …

Objective Complex local crosstalk amongst endocrine cells within the islet ensures tight
coordination of their endocrine output. This is illustrated by the recent demonstration that the …

A primary cause of disease progression in type 2 diabetes (T2D) is β cell dysfunction due to
inflammatory stress and insulin resistance. However, preventing β cell exhaustion under …