Experimental work during the past 15 years has demonstrated that endothelial cells in the
heart play an obligatory role in regulating and maintaining cardiac function, in particular, at …

Heart failure (HF) is a major cause of morbidity and mortality with more than 5.1 million
individuals affected in the USA. Ventricular tachyarrhythmias (VAs) including ventricular …

МНЕНИЕ ЭКСПЕРТА (p< 0,001). Подобные результаты были получены и в
исследованиях ARIC и UKPDS: снижение HbA1c на 1% уменьшало риск ИМ на 14 …

Dysregulated intracellular Ca2+ handling involving altered Ca2+ release from intracellular
stores via RyR channels underlies both arrhythmias and reduced function in heart failure …

Rationale: Excessive vasoconstriction in response to mental stress may be a potential
mechanism by which acute psychological stress leads to adverse cardiac events …

A multitude of factors, including increased coronary vascular resistance and dysregulated
coronary microcirculatory function, contribute to the impairment of coronary blood flow (CBF) …

Abstract Endothelin-1 (ET-1), the predominant isoform of the ET peptide family and a potent
vasoconstrictor, has been shown to aggravate ischemia-induced ventricular arrhythmias …

Abstract Objective: Endothelin-1 (ET-1) production increases during acute myocardial
infarction (MI) and may contribute to the genesis of ventricular tachycardia (VT) and …

ARONSON, D., et al.: Neurohumoral Activation and Ventricular Arrhythmias in Patients with
Decompensated Congestive Heart Failure: Role of Endothelin. Patients with congestive …

Ventricular arrhythmogenesis during acute coronary syndromes is a common cause of
sudden cardiac death, but the underlying mechanisms remain incompletely understood …