Cyclic peptides are promising scaffolds for drug development, attributable in part to their
increased conformational order compared to linear peptides. However, when optimizing the …

Theranostics are drugs suitable for use in both diagnostic and therapeutic applications, and
have played an important role in the advancement of modern nuclear medicine. This review …

Chaperone oligomerization is often a key aspect of their function. Irrespective of whether
chaperone oligomers act as reservoirs for active monomers or exhibit a chaperoning …

Constrained, membrane-permeable peptides offer the possibility of engaging challenging
intracellular targets. Structure-permeability relationships have been extensively studied in …

Naturally occurring cationic antimicrobial peptides (AMPs) mostly adopt α-helical structures
in bacterial membrane mimetic environments. To explore the design of novel β-sheet AMPs …

Biocatalysis based on enzyme catalysis is becoming increasingly popular. However, few
enzymes can directly catalyze the desired reaction, it is necessary to modify the catalyst to …

The purpose of this study was to investigate whether Human Serum Albumin (HSA) can bind
N-methylated analogs of hot spots of native insulin. Three N-methylated derivatives of the …

Abstract The bacterial toxin CcdB (Controller of Cell death or division B) targets DNA
Gyrase, an essential bacterial topoisomerase, which is also the molecular target for …

Amide peptide backbone methylation is a characteristic post-translational modification found
in a family of ribosomally synthesized and post-translationally modified peptide natural …

A significant challenge in chemical biology is to understand and modulate protein–protein
interactions (PPIs). Given that many PPIs involve a folded protein domain and a peptide …