The glycine receptor chloride channel (GlyR) is a member of the nicotinic acetylcholine
receptor family of ligand-gated ion channels. Functional receptors of this family comprise five …

The conversion of acetylcholine binding into ion conduction across the membrane is
becoming more clearly understood in terms of the structure of the receptor and its transitions …

Fast inhibitory neurotransmission is essential for nervous system function and is mediated
by binding of inhibitory neurotransmitters to receptors of the Cys-loop family embedded in …

We present a refined model of the membrane-associated Torpedo acetylcholine (ACh)
receptor at 4Å resolution. An improved experimental density map was obtained from 342 …

The nicotinic acetylcholine receptor controls electrical signalling between nerve and muscle
cells by opening and closing a gated, membrane-spanning pore. Here we present an atomic …

1. Introduction 3261.1 What? Terminology and general properties 3271.2 Why? Reasons for
biophysical study 3291.3 How? Special issues for study of connexin channels 3302 …

nAChRs are pentameric transmembrane proteins into the superfamily of ligand-gated ion
channels that includes the 5HT3, glycine, GABAA, and GABAC receptors. Electron …

Cys-loop receptors are membrane-spanning neurotransmitter-gated ion channels that are
responsible for fast excitatory and inhibitory transmission in the peripheral and central …

Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels and can be
divided into two groups: muscle receptors, which are found at the skeletal neuromuscular …

The structure of the open-channel form of the acetylcholine receptor has been determined
from electron images of Torpedo ray postsynaptic membranes activated by brief (< 5ms) …