The field of psychiatry is hampered by a lack of robust, reliable and valid biomarkers that can
aid in objectively diagnosing patients and providing individualized treatment …

Cognitive impairment is a core feature of schizophrenia and a major contributor to poor
functional outcomes. Methods for assessment of cognitive dysfunction in schizophrenia are …

The current management of patients with primary psychosis worldwide is often remarkably
stereotyped. In almost all cases an antipsychotic medication is prescribed, with second …

Cognitive impairment is a hallmark of schizophrenia and a robust predictor of functional
outcomes. Impairments are found in all phases of the illness and are only moderately …

Cognitive impairments are pervasive and disabling features of schizophrenia. Targeted
cognitive training (TCT) is a “bottom-up” cognitive remediation intervention with efficacy for …

Objectives Neurocognitive deficits are central in schizophrenia. Cognitive remediation has
proven effective in alleviating these deficits, with medium effect sizes. However, sizeable …

Schizophrenia is a major mental disorder that affects approximately 1% of the population
worldwide. Cognitive deficits are a key feature of the disorder and a primary cause of long …

The thalamus is a subcortical structure formed by different nuclei that relay information to the
neocortex. Several reports have already described alterations of this structure in patients of …

Twenty years ago, cognitive impairments were recognized as an unmet treatment need in
schizophrenia. Basic science discoveries in neuroplasticity had led to cognitive training …

Background Psychiatry aspires to the molecular understanding of its disorders and, with that
knowledge, to precision medicine. Research supporting such goals in the dimension of …