Understanding how individual neurons integrate the thousands of synaptic inputs they
receive is critical to understanding how the brain works. Modeling studies in silico and …

Understanding the mechanisms that underlie learning is one of the most fascinating and
central aims of neurobiological research. Hippocampal long-term potentiation (LTP) is …

Learning is primarily mediated by activity-dependent modifications of synaptic strength
within neuronal circuits. We discovered that place fields in hippocampal area CA1 are …

The brain has an extraordinary capacity for memory storage, but how it stores new
information without disrupting previously acquired memories remains unknown. Here we …

Pyramidal neurons are characterized by their distinct apical and basal dendritic trees and
the pyramidal shape of their soma. They are found in several regions of the CNS and …

How learning and memory is achieved in the brain is a central question in neuroscience.
Key to today's research into information storage in the brain is the concept of synaptic …

Aiming at a formulation of a cytokine model of cognitive function under immunologically
unchallenged physiological conditions, this article reviews the cytokine biology in the central …

Electrophysiological connectivity patterns in cortex often have a few strong connections,
which are sometimes bidirectional, among a lot of weak connections. To explain these …

Calcium/calmodulin-dependent kinase II (CaMKII) plays a central part in long-term
potentiation (LTP), which underlies some forms of learning and memory. Here we monitored …

Most synaptic inputs are made onto the dendritic tree. Recent work has shown that dendrites
play an active role in transforming synaptic input into neuronal output and in defining the …